Stress Paradigms, Attentional Bias, and Craving for Cigarettes and Opioids

This spreadsheet encompasses data for a lab based experiment. We simultaneously administered two validated stress paradigms to model physical (cold pressor test [CPT]) and psychological stress (paced auditory serial addition task [PASAT]) in people with OUD who smoke (n=14), stabilized on medications for OUD. We examined the effects of stress on cigarette and opioid craving and attentional bias (AB) for both cigarette cues and opioid cues using an eye tracker. The data presented in this manuscript was acquired as part of a randomized controlled trial (RCT) comparing the effects of four sessions of active versus sham intermittent theta burst stimulation (iTBS) versus sham iTBS on craving and cue-based AB for cigarettes and opioids (NCT05049460). All data in the present study were from baseline assessments collected before iTBS/sham iTBS. The study was approved by the Institutional Review Board at the University of Kentucky College of Medicine. Column 1 is the unique participant identification number, column 2 lists time points ( 0 being baseline and 1 being after stress), column 3 listing cue types (1 being cues of people smoking cigarettes or using opioids, 2 being cues of cigarette paraphernalia or opioid paraphernialia), column 4 lists Fagerstrom scores of participants, column 5 lists cigarette craving scores (Short version of Tobacco Craving Questionnaire, TCQ-SF), column 6 lists cue based AB for cigarette cues in milliseconds, column 7 lists opioid craving scores (opioid craving scale, OCS), column 8 lists cue based AB for opioid cues.本数据集包含一项实验室实验的相关研究数据。我们对14名接受阿片使用障碍（Opioid Use Disorder, OUD）药物稳定治疗的吸烟受试者，同时实施两种经过验证的应激范式，以分别模拟躯体应激（冷加压试验[CPT]）与心理应激（持续性听觉序列加法任务[PASAT]）。本研究采用眼动仪，探究了应激对香烟渴求、阿片渴求，以及香烟线索与阿片线索的注意偏向（Attentional Bias, AB）的影响。本手稿所载数据来源于一项随机对照试验（Randomized Controlled Trial, RCT）的子项目，该试验旨在对比4次主动间歇性theta爆发刺激（intermittent theta burst stimulation, iTBS）与假间歇性theta爆发刺激对香烟及阿片渴求、线索相关注意偏向的影响，临床试验注册号为NCT05049460。本研究的所有数据均采集于间歇性theta爆发刺激/假刺激干预前的基线评估阶段。本研究已通过肯塔基大学医学院伦理审查委员会的伦理审查。数据集各列信息如下：第1列为受试者唯一识别编号；第2列为时间点（0代表基线，1代表应激干预后）；第3列为线索类型（1为吸烟或使用阿片类物质的人物线索，2为香烟烟具或阿片使用器具线索）；第4列为受试者的费尔斯特伦评分；第5列为香烟渴求评分（采用烟草渴求问卷简版[Short version of Tobacco Craving Questionnaire, TCQ-SF]）；第6列为香烟线索相关注意偏向的毫秒级测量值；第7列为阿片渴求评分（采用阿片渴求量表[Opioid Craving Scale, OCS]）；第8列为阿片线索相关注意偏向的测量值。