Crystal Structure of HIV-1 BG505 SOSIP.664 Prefusion Env Trimer Bound to Small Molecule HIV-1 Entry Inhibitor BMS-378806 in Complex with Human Antibodies 3H109L and 35O22 at 2.9 Angstrom

Crystal Structure of HIV-1 BG505 SOSIP.664 Prefusion Env Trimer Bound to Small Molecule HIV-1 Entry Inhibitor BMS-378806 in Complex with Human Antibodies 3H109L and 35O22 at 2.9 Angstrom Descriptor: 1-[(2R)-4-(benzenecarbonyl)-2-methylpiperazin-1-yl]-2-(4-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)ethane-1,2-dione, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Lai, Y.-T, Kwong, P.D. Deposit date: 2018-10-19 Release date: 2019-01-16 Last modified: 2024-11-06 Method: X-RAY DIFFRACTION (2.336 Å) Cite: Lattice engineering enables definition of molecular features allowing for potent small-molecule inhibition of HIV-1 entry. Nat Commun, 10, 2019

分辨率2.9埃的HIV-1 BG505 SOSIP.664预融合包膜糖蛋白（Env）三聚体与小分子HIV-1进入抑制剂BMS-378806、人源抗体3H109L及35O22形成复合物的晶体结构
描述项：1-[(2R)-4-(苯甲酰基)-2-甲基哌嗪-1-基]-2-(4-甲氧基-1H-吡咯并[2,3-b]吡啶-3-基)乙烷-1,2-二酮、2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖、2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖-(1→4)-2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖……
作者：Lai, Y.-T、Kwong, P.D.
入库日期：2018-10-19
发布日期：2019-01-16
最后修改日期：2024-11-06
实验方法：X射线衍射（分辨率2.336埃）
引用文献：晶格工程实现对小分子强效抑制HIV-1进入的分子特征的解析。《自然-通讯》，10卷，2019年