Analysis of expression of genes involved in celiac disease. Homo sapiens

Celiac disease (CD) is a chronic immune-mediated disorder with an important genetic component. We analyzed the expression of candidate genes in biopsies from duodenum. Overall design: The sample set consisted of duodenal biopsies from 15 CD children at diagnosis (on a gluten-containing diet, with CD-associated antibodies, atrophy of intestinal villi and crypt hyperplasia), and the same patients in remission after being treated with gluten-free diet (GFD) for >2 years (asymptomatic, antibody negative, and normalized intestinal epithelium at that time), plus 15 tissue samples from non-celiac individuals not suffering from inflammation at the time of endoscopy, used as controls.