FBL facilitates interstrand DNA crosslink repair by 2'-O-methylating FANCD2 mRNA of congwen gao .sample et al.
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Our findings uncover a novel epitranscriptional mechanism governing ICL repair, wherein FBL-dependent methylation of FANCD2 mRNA ensures genomic stability. This represents a previously unrecognized role of FBL in ICL repair. These results not only expand our understanding of FA pathway regulation but also provide insights into the molecular basis of FA-related hematologic disorders.
