Reconstructed Individual Patient Data and Analysis Code: First-Line Chemoimmunotherapy in Extensive-Stage Small Cell Lung Cancer (ES-SCLC Network Meta-Analysis)

This deposit accompanies the manuscript "Months of Life Gained with First-Line Chemoimmunotherapy in Extensive-Stage Small Cell Lung Cancer: A Bayesian Network Meta-Analysis of Reconstructed Individual Patient Data" (manuscript ID JTD-2026-2838, under review at Journal of Thoracic Disease). Contents (see README.md for details): ipd/: reconstructed arm-level individual patient data for 10 phase III randomized trials (N = 4,663; overall survival and progression-free survival), derived from published Kaplan-Meier curves using KM-PoPiGo. Trials: ASTRUM-005, BEAT-SC, CAPSTONE-1, CASPIAN, ETER701, EXTENTORCH, IMpower133, KEYNOTE-604, RATIONALE-312, ZKAB001-301. km_coordinates/: digitized Kaplan-Meier curve markup (37 JSON files) in KM-PoPiGo session format; loading a file in KM-PoPiGo together with the published curve image restores the full digitization session. code/: R and Python scripts reproducing all analyses (pairwise RMSTD with survRM2; Bayesian M-spline network meta-analysis with multinma; trajectory anchoring; knot/prior/random-effects sensitivity analyses; Monte Carlo reconstruction-error propagation; CINeMA-style certainty ratings). Reproduced result tables (pairwise RMSTD, sensitivity analyses, Monte Carlo summary, certainty ratings). Validation: reconstructed landmark survival deviates from published values by no more than 0.5 percentage points; reconstructed single-trial hazard ratios agree with published values within 0.06. Reuse: these data are reconstructed approximations derived from published figures and are provided for methodological transparency and reproducibility; they must not be redistributed as primary trial data. Please cite both the manuscript and the original trial publications when reusing.