Fibrosis
收藏NIAID Data Ecosystem2026-05-10 收录
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Transforming growth factor-β1 (TGF-β1) is a crucial mediator of fibrosis by activating downstream small mother against decapentaplegic (Smad) signaling which triggers pro-fibrotic genes overexpression. Smad3 is the major downstream regulator that promote TGF-β mediated tissue fibrosis, while Smad7 protects against fibrosis inhibiting the TGF-β1/Smad pathway. The renin-angiotensin system (RAS) also controls the fibrotic process.
创建时间：
2025-11-26
