Elucidating the oncogenic role of Menin in prostate cancer progression

Menin protein is encoded by the multiple endocrine neoplasia type 1 (MEN1) gene. It remains an enigmatic protein, known as a tumor suppressor but its roles in cancer development have attracted significant attention in recent years. The goals of this study is to understand how the Menin tumor suppressor can be oncogenic in Prostate, we have profiled Menin chromatin occupancy by chromatin immunoprecipitation coupled to high-throughput DNA sequencing (ChIP-seq) in the normal prostate model (PNT1A) and in a different stage of prostate cancer CS model (LNCaP) and CR model (PC-3). Examination of the potential genetic changes in 3 differents cell line PNT1a, LNCaP and PC-3.