Clinical significance of MSP-RON signaling based on mRNA-microRNA integration analyses in acute severe ischemic stroke patients (micro RNA data)

The roles of mRNA and microRNA (miRNA) are widely known in many diseases including acute ischemic stroke. About 60 % of all human messenger RNAs (mRNAs) are regulated by microRNAs. Integration analysis using mRNA and miRNA are important to elucidate pathogenesis. But the contribution of mRNA and miRNA, especially miRNA targeted mRNA, related with severity of acute ischemic stroke is not remain understood. To clarify the pathway related with the severity of acute ischemic stroke, we examined mRNA and miRNA integration analysis targeted for acute ischemic stroke. Overall design: We corrected RNA extracted from whole blood of 6 acute minor ischemic stroke patients (National Institutes of Health Stroke Scale [NIHSS] < 8) and 6 acute severe ischemic stroke patients (NIHSS = 8) on admission. mRNA and miRNA were measured by RNA sequencing.