Expression data from Cord blood and Peripheral blood derived macrophages

The risk of sepsis is particularly high in neonates compared to older children and adults; however the reasons behind are incompletely understood. Macrophages are at the front line of the innate immune system and differentiate from monocytes after infiltrating the infected tissue. We studied transcriptional differences between cord blood-derived in vitro activated macrophages and adult peripheral blood derived in vitro actiavted macrophages. We used microarrays to detail the global programme of gene expression in cord blood derived M(IL-10) and M(IFN-γ) and in adult blood derived M(IL-10) and M(IFN-γ)macropahges Genome-wide transcriptome analyses for cord blood derived M(IL-10) and M(IFN-γ) and for adult blood derived M(IL-10) and M(IFN-γ)macropahges were performed in independent triplicates using HTA-2 arrays