Retrospective gene expression analysis of human RNA samples from Hepatocellular Carcinoma in relation with survival

The aim of this study is to identify by Next Generation Sequencing - RNA-seq profiling a molecular signature of Hepatocellular Carcinoma samples that correlates with survival. The samples were retrospectively derived from hepatocellular carcinoma tissue as well as non-tumor tissue from the livers of the same patients. The bioinformatical analysis of 32 pairs RNA-seq datasets were obtained from human RNAs on Illumina Hiseq-PE150. Due to the lack of biological sample duplication, this datasets were used hisat2 2.1.0 and gfold v1.1.4 for expression analysis to identify differences in gene expression between tumors and adjacent tissues. (including up- and down-regulation). Overall design: mRNA profiles of 32 pairs of hepatocellular carcinoma tissue as well as non-tumor tissue from the livers of the same patients were generated by Next Generation Sequencing - RNA-seq, using Illumina Hiseq-PE150. ***Please note that the processed data was updated on Jan 9, 2020.