Asymmetric Ring Opening of Oxabicyclic Alkenes: Enhanced Rhodium Catalysis Using Camphor-Derived NHC Ligands Featuring Pyridine Coordination

The synthesis, characterization,
and reactivity assessment of a
chiral camphor-based Rh(I) catalyst functionalized with a pyridine
moiety is presented. The catalytic system was evaluated in the asymmetric
ring opening (ARO) of bicyclic alkene substrates, ensuring high product
yields and enantioselectivity. While the primary focus was on the
use of indoles as nucleophiles in the ARO reaction, a broader scope
of bicyclic substrates was also explored. The catalyst demonstrated
tolerance toward various functional groups present in the nucleophiles,
underscoring its broad synthetic utility in asymmetric synthesis.