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Gene expression profiling of bone marrow and lung ILC2s

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https://www.ncbi.nlm.nih.gov/sra/SRP394310
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We found that CD45, a membrane bound tyrosine phosphatase important for T cell development, negatively regulated ILC2s in a cell-intrinsic manner. ILC2s in CD45-deficient mice exhibited enhanced proliferation and maturation in bone marrow and hyperactivated phenotypes in lung with alteration of cell metabolism. Overall design: Examination two hundred of ILC2s freshly sorted from bone marrow and lung of CD45-deficient and control mice
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2023-10-29
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