Supporting data for "Nidogen-1 modulates type 2 conventional dendritic cell infiltration and builds an immunosuppressive microenvironment in hepatocellular carcinoma"

These are supporting data for a Master of Philosophy thesis titled "Nidogen-1 modulates type 2 conventional dendritic cell infiltration and builds an immunosuppressive microenvironment in hepatocellular carcinoma". This repository contains raw data and a processed data file for analysis. This study investigated the role of nidogen-1 in regulating the tumor immune microenvironment in hepatocellular carcinoma. The association between tumor nidogen-1 expression, type 2 conventional dendritic cell infiltration, and tumor development has been unveiled in this study, highlighting the significance of the tolerogenic roles of nidogen-1 and the infiltrated type 2 conventional dendritic cells, which together promote tumor development. The findings of this study are expected to provide insights for further investigations into the specific mechanisms underlying the interaction between nidogen-1 and conventional dendritic cells in hepatocellular carcinoma and ultimately contribute to the development of novel immunotherapeutic approaches.

本数据集为题为《Nidogen-1调节肝细胞癌中2型传统树突状细胞浸润并构建免疫抑制性微环境》的哲学硕士学位论文提供支持性数据。该仓库包含原始数据及用于分析的预处理数据文件。本研究旨在探讨Nidogen-1在调节肝细胞癌肿瘤免疫微环境中的作用。本研究揭示了肿瘤Nidogen-1表达、2型传统树突状细胞浸润与肿瘤发展之间的关联，凸显了Nidogen-1及其浸润的2型传统树突状细胞所发挥的诱导耐受作用，二者共同促进肿瘤发展。本研究的发现有望为深入探究Nidogen-1与传统树突状细胞在肝细胞癌中相互作用的具体机制提供洞见，并最终为开发新型免疫治疗策略作出贡献。