Clinical symptoms of right ventricular failure in experimental chronic pressure load are associated with progressive diastolic dysfunction

Chronic pulmonary artery banding invariably leads to RV failure in rats, and a subset transitions to advanced clinical RVF. RVF is characterized by enhanced contractility, progressive diastolic dysfunction and derangement of energy metabolism, thus improving diastolic function and targeting RV metabolism may be the keys to treating RVF.慢性肺动脉环扎术（Chronic pulmonary artery banding）可使大鼠无一例外地发生右心室（Right Ventricle, RV）衰竭，且部分亚组大鼠进展为临床进展性右心衰竭（Right Ventricular Failure, RVF）。右心衰竭以收缩功能代偿增强、进行性舒张功能障碍及能量代谢紊乱为特征，因此改善舒张功能并靶向调控右心室能量代谢或为治疗右心衰竭的关键策略。