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Avoidance of sulfur loss during ammonia treatment of oligonucleotide phosphorothioates.

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PubMed Central1997-07-15 更新2026-05-25 收录
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Sulfur loss during the unblocking of phosphorothioate analogues of oligonucleotides with concentrated aqueous ammonia can be completely suppressed by the addition of 2-mercaptoethanol.

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1997-07-15
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