Transcriptional responses to chronic oxidative stress in skeletal muscle

We measured gene expression differences in the extensor digitorum longus (edl) skeletal muscle between wild-type and mice lacking Cu, Zn-superoxide dismutase to determine the effect of chronic oxidative stress on skeletal muscle. We analyzed 4 edl samples from WT mice and 4 samples from the SOD1 knockouts.本研究以趾长伸肌（extensor digitorum longus, EDL）骨骼肌为实验对象，检测野生型（wild-type）小鼠与铜锌超氧化物歧化酶（Cu, Zn-superoxide dismutase）敲除小鼠之间的基因表达差异，以明确慢性氧化应激对骨骼肌的影响。本研究共分析了4份野生型（WT）小鼠的趾长伸肌样本，以及4份SOD1敲除小鼠的趾长伸肌样本。