Raw Data for Figure 3

Haemodynamic monitoring in TRPV4 WT and KO mice under basal and endotoxaemic conditions. Values were taken following systemic treatment (WT mice only) with HC-067047 (HC) or vehicle (10% DMSO) (BL2) and after induction of endotoxaemia (at time 48h: LPS, 12.5mg/kg, i.v.). Boxed regions denote periods of darkness. Data were acquired by radiotelemetry in conscious, ambulatory male C57BL/6 mice.本数据集针对瞬时受体电位阳离子通道V4（TRPV4）野生型（WT）与敲除型（KO）小鼠，开展基础状态及内毒素血症条件下的血流动力学监测。检测数据采集于两个时间节点：一是系统给药后（仅针对野生型小鼠），给药组给予HC-067047（HC）处理，对照组给予赋形剂（10%二甲基亚砜，即BL2）；二是内毒素血症造模后，造模于48小时时进行，采用脂多糖（LPS）12.5mg/kg静脉注射给药。带框区域代表黑暗时段。本实验数据通过无线遥测技术，对清醒且可自由活动的雄性C57BL/6小鼠完成采集。