PCSK9 AZD0780 complex

PCSK9 AZD0780 complex Descriptor: 1-[6-[[(1~{S},3~{S})-3-[[5-[bis(fluoranyl)methoxy]pyrimidin-2-yl]amino]cyclopentyl]amino]pyridin-3-yl]pyridin-2-one, Proprotein convertase subtilisin/kexin type 9 Authors: Johansson, P. Deposit date: 2025-01-13 Release date: 2026-05-27 Last modified: 2026-07-01 Method: X-RAY DIFFRACTION (1.432 Å) Cite: Laroprovstat, the First Oral Small-Molecule PCSK9 Inhibitor for the Treatment of Hypercholesterolemia: Results From a Randomized, Single-Blind, Placebo-Controlled Phase 1 Trial in Treatment-Naive Patients. Circulation, 153, 2026