Amyloidogenic regions in the PFDs of hnRNPA1 and hnRNPA2.

The highest pWALTZ scoring windows and the pWALTZ values for these sequences are shown for the wild type, pathogenic and deleted variants of the proteins. Positions in which natural mutations occur are shown in bold, deleted regions in Δ mutants are underlined.
(a)Variants with reduced amyloid propensity relative to the wild type sequence.
(b)Variants that can substitute for the Sup35 nucleation domain in supporting prion formation and promote the nucleation activity in yeast.
Amyloidogenic regions in the PFDs of hnRNPA1 and hnRNPA2.