Parameter optimization for clustering of consensus helix architectures.

aAll: All SC-clusters from the classification dataset; ≤7 TMHs: SC-clusters with members having up to seven TMHs; >7 TMHs: SC-clusters with members having more than seven TMHs.
bSensitivity: Fraction of all proteins pairs having the same Pfam annotation that were assigned to the same HIS cluster using the respective HISS score threshold and inflation value.
cSpecificity: Fraction of all proteins pairs having different Pfam annotations that were assigned to different HIS clusters using the respective HISS score threshold and inflation value.