Variants Significantly Associated with Circulating Sphingolipid Concentrations.

22 variants in 7 genes located in 5 distinct chromosomal locations demonstrate genome-wide significant association signals with several measured single sphingolipid species (listed). The p-value ranges for significant signals across the sphingolipid species are shown for each population separately and jointly, and the direction of the association effects, as derived from the standardized regression coefficient (β), is summarized. Detailed results for each species along with specific β values are shown in Table S1. Abbreviations sphingomyelin (SM), dihydrosphingomyelin (dihSM), ceramide (Cer) and glucosylceramide (GluCer) unsaturated ceramides (CerUnsat), saturated ceramides (CerSat). In the nomenclature (e.g. SM18:0), the number before the colon refers to length of the carbon chain and the number after the colon to the number of double bonds in the chain. Additional variants uncovered in the matched metabolite ratio analysis can be found in Table S3. Alleles correspond to Illumina TOP notation.