Crystal structure of glycosyltransferase SgUGT94-289-3 in complex with SIA, state 3

Crystal structure of glycosyltransferase SgUGT94-289-3 in complex with SIA, state 3 Descriptor: (20S)-2,5,8,11,14,17-HEXAMETHYL-3,6,9,12,15,18-HEXAOXAHENICOSANE-1,20-DIOL, (2S,3S,4S,5R,6R)-2-(hydroxymethyl)-6-[[(2S,3S,4S,5R,6S)-5-[(2S,3R,4S,5S,6S)-6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]oxy-6-[(3R,6S)-6-[(3S,8S,9R,10R,11S,13R,14S,17R)-3-[(2S,3R,4S,5S,6S)-6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]oxy-4,4,9,13,14-pentamethyl-11-oxidanyl-2,3,7,8,10,11,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-methyl-2-oxidanyl-heptan-3-yl]oxy-3,4-bis(oxidanyl)oxan-2-yl]methoxy]oxane-3,4,5-triol, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... Authors: Li, M, Zhang, S, Cui, S. Deposit date: 2022-11-23 Release date: 2024-05-29 Last modified: 2024-08-14 Method: X-RAY DIFFRACTION (1.76 Å) Cite: Structural insights into the catalytic selectivity of glycosyltransferase SgUGT94-289-3 towards mogrosides. Nat Commun, 15, 2024

与SIA结合的糖基转移酶（glycosyltransferase）SgUGT94-289-3的晶体结构，状态3。结构描述项：1. (20S)-2,5,8,11,14,17-六甲基-3,6,9,12,15,18-六氧杂二十一烷-1,20-二醇；2. (2S,3S,4S,5R,6R)-2-(羟甲基)-6-[[(2S,3S,4S,5R,6S)-5-[(2S,3R,4S,5S,6S)-6-(羟甲基)-3,4,5-三(羟基)氧杂环己-2-基]氧基-6-[(3R,6S)-6-[(3S,8S,9R,10R,11S,13R,14S,17R)-3-[(2S,3R,4S,5S,6S)-6-(羟甲基)-3,4,5-三(羟基)氧杂环己-2-基]氧基-4,4,9,13,14-五甲基-11-羟基-2,3,7,8,10,11,12,15,16,17-十氢-1H-环戊并[a]菲-17-基]-2-甲基-2-羟基-庚烷-3-基]氧基-3,4-二(羟基)氧杂环己-2-基]甲氧基]氧杂环己-3,4,5-三醇；3. 2-氨基-2-羟甲基-丙烷-1,3-二醇，……。作者：Li, M、Zhang, S、Cui, S。沉积日期：2022年11月23日；发布日期：2024年5月29日；最后修改日期：2024年8月14日。实验方法：X射线衍射（分辨率1.76 Å）。引用文献：《Structural insights into the catalytic selectivity of glycosyltransferase SgUGT94-289-3 towards mogrosides》，《自然·通讯》（Nat Commun），第15卷，2024年。