Crystal Structure of the Catalytic Domain of the Inosine Monophosphate Dehydrogenase from Bacillus anthracis in the complex with IMP and the inhibitor P176
收藏Protein Data Bank Japan2026-03-25 更新2026-03-21 收录
下载链接：
https://pdbj.org/mine/summary/7mtx
下载链接
链接失效反馈官方服务：
资源简介：
Crystal Structure of the Catalytic Domain of the Inosine Monophosphate Dehydrogenase from Bacillus anthracis in the complex with IMP and the inhibitor P176 Descriptor: INOSINIC ACID, Inosine-5'-monophosphate dehydrogenase, N-{2-chloro-5-[({2-[3-(prop-1-en-2-yl)phenyl]propan-2-yl}carbamoyl)amino]phenyl}-beta-D-ribopyranosylamine, ... Authors: Kim, Y, Maltseva, N, Makowska-Grzyska, M, Gu, M, Gollapalli, D, Hedstrom, L, Anderson, W.F, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) Deposit date: 2021-05-13 Release date: 2021-06-09 Last modified: 2026-03-25 Method: X-RAY DIFFRACTION (2.44 Å) Cite: The Enzymatic Activity of Inosine 5'-Monophosphate Dehydrogenase May Not Be a Vulnerable Target for Staphylococcus aureus Infections. Acs Infect Dis., 7, 2021
炭疽芽孢杆菌（Bacillus anthracis）来源的肌苷单磷酸脱氢酶（Inosine Monophosphate Dehydrogenase）催化结构域与肌苷-5'-单磷酸（Inosine-5'-monophosphate，IMP）及抑制剂P176复合物的晶体结构
标识符：肌苷酸（INOSINIC ACID）、肌苷-5'-单磷酸脱氢酶（Inosine-5'-monophosphate dehydrogenase）、N-{2-氯-5-[({2-[3-(丙-1-烯-2-基)苯基]丙-2-基}氨基甲酰基)氨基]苯基}-β-D-吡喃核糖胺，……
作者：Kim Y、Maltseva N、Makowska-Grzyska M、Gu M、Gollapalli D、Hedstrom L、Anderson W.F.、Joachimiak A，传染病结构基因组学中心（Center for Structural Genomics of Infectious Diseases, CSGID）
提交日期：2021-05-13
发布日期：2021-06-09
最后修改日期：2026-03-25
实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率2.44埃
引用文献：《肌苷5'-单磷酸脱氢酶的酶活或并非金黄色葡萄球菌（Staphylococcus aureus）感染的易感靶点》，ACS Infectious Diseases，7卷，2021年
创建时间：
2021-05-13
