Crystal structure of VPS34 in complex with inhibitor SB02024

Crystal structure of VPS34 in complex with inhibitor SB02024 Descriptor: 4-[(3R)-3-methylmorpholin-4-yl]-2-[(2R)-2-(trifluoromethyl)piperidin-1-yl]-3H-pyridin-6-one, DI(HYDROXYETHYL)ETHER, DIMETHYL SULFOXIDE, ... Authors: Tresaugues, L, Yu, Y, Bogdan, M, Parpal, S, Silvander, C, Lindstrom, J, Simeon, J, Timson, M.J, Al-Hashimi, H, Smith, B.D, Flynn, D.L, Viklund, J, Martinsson, J, De Milito, A, Andersson, M. Deposit date: 2024-02-07 Release date: 2024-03-20 Last modified: 2024-08-21 Method: X-RAY DIFFRACTION (2.06 Å) Cite: Combining VPS34 inhibitors with STING agonists enhances type I interferon signaling and anti-tumor efficacy. Mol Oncol, 18, 2024与抑制剂SB02024结合的VPS34晶体结构 组分：4-[(3R)-3-甲基吗啉-4-基]-2-[(2R)-2-(三氟甲基)哌啶-1-基]-3H-吡啶-6-酮、二(羟乙基)醚、二甲基亚砜等 作者：Tresaugues L、Yu Y、Bogdan M、Parpal S、Silvander C、Lindstrom J、Simeon J、Timson MJ、Al-Hashimi H、Smith BD、Flynn DL、Viklund J、Martinsson J、De Milito A、Andersson M 沉积日期：2024-02-07 发布日期：2024-03-20 最后修改日期：2024-08-21 实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率2.06 Å 引用文献：将VPS34抑制剂与STING激动剂联合使用可增强I型干扰素信号通路与抗肿瘤功效。《分子肿瘤学》（Mol Oncol），第18卷，2024年