Structural Insights into the Design of Nonpeptidic Isothiazolidinone- Containing Inhibitors of Protein Tyrosine Phosphatase 1B

Structural Insights into the Design of Nonpeptidic Isothiazolidinone- Containing Inhibitors of Protein Tyrosine Phosphatase 1B Descriptor: MAGNESIUM ION, METHYL 2-{[5-({3-CHLORO-4-[(5S)-1,1-DIOXIDO-3-OXOISOTHIAZOLIDIN-5-YL]-N-(PHENYLSULFONYL)-L-PHENYLALANYL}AMINO)PENTYL]OXY}-6-HYDROXYBENZOATE, TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 1 Authors: Ala, P.J, Gonneville, L, Hillman, M, Becker-Pasha, M, Yue, E.W, Douty, B, Wayland, B, Polam, P, Crawley, M.L, McLaughlin, E, Sparks, R.B, Glass, B, Takvorian, A, Combs, A.P, Burn, T.C, Hollis, G.F, Wynn, R. Deposit date: 2006-05-21 Release date: 2006-09-27 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (2 Å) Cite: Structural Insights Into the Design of Nonpeptidic Isothiazolidinone-Containing Inhibitors of Protein- Tyrosine Phosphatase 1B. J.Biol.Chem., 281, 2006

蛋白酪氨酸磷酸酶1B（Protein Tyrosine Phosphatase 1B）非肽类含异噻唑啉酮（Isothiazolidinone）抑制剂的设计结构研究
数据集描述项：镁离子、2-{[5-({3-氯-4-[(5S)-1,1-二氧代-3-氧代异噻唑啉-5-基]-N-(苯磺酰基)-L-苯丙氨酰}氨基)戊基]氧基}-6-羟基苯甲酸甲酯、非受体型1型酪氨酸蛋白磷酸酶（TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 1）
作者：Ala P.J、Gonneville L、Hillman M、Becker-Pasha M、Yue E.W、Douty B、Wayland B、Polam P、Crawley M.L、McLaughlin E、Sparks R.B、Glass B、Takvorian A、Combs A.P、Burn T.C、Hollis G.F、Wynn R
提交日期：2006年5月21日
发布日期：2006年9月27日
最后修改日期：2024年5月8日
实验方法：X射线衍射（X-RAY DIFFRACTION，分辨率2 Å）
引用文献：Structural Insights Into the Design of Nonpeptidic Isothiazolidinone-Containing Inhibitors of Protein-Tyrosine Phosphatase 1B. J. Biol. Chem., 281, 2006