T1-DEXi-T Study: Does exercise training improve the time in range following acute bouts of exercise?

Building on our recently funded T1DHome study, we are excited to propose an expansion of the recent T1DEXi study by investigating the impact of regular exercise training and detraining on various blood glucose metrics following acute bouts of exercise in adult men and women with T1D. We refer to this proposed study as the T1-DEXI Training Study (T1-DEXi-T study).

Our proposed work aims to inform new clinical guidelines for exercise for adults living with type 1 diabetes. While existing guidelines mention an exercise “prescription” they are not well tailored for adults living with type 1 diabetes who may benefit from a more targeted exercise training prescription that should improve cardiometabolic and skeletal muscle health along with enhancing global TIR metrics for this patient population. While the T1DEXi study serves as a critical database, it was not a training intervention and no objective measures of cardiometabolic and skeletal muscle health were made. The T1DHome follow-up study is a natural progression for this important first step in improving the health and wellbeing through regular exercise of people living with type 1 diabetes but the CGM TIR metrics analyses and exercise wearable portion of this study is not yet funded. We propose that the Leona M. and Harry B. Helmsley Charitable Trust offer research support for the use of CGM, exercise wearables (Garmin) and deep data analytics for the first phase of the T1DHome study.