A Water-Soluble Cyclotriveratrylene-Based Supra-amphiphile: Synthesis, pH-Responsive Self-Assembly in Water, and Its Application in Controlled Drug Release

A new water-soluble
cyclotriveratrylene (WCTV) was designed and
synthesized, and benzyldimethyldodecylammonium chloride (G) was chosen
as the guest molecule to construct a supra-amphiphile by the host–guest
interaction between WCTV and G in water, which is pH responsive. The
supra-amphiphiles self-assembled into vesicles in water. When the
pH of the solution was below 7.0, the supra-amphiphile disassociated,
and the vesicles collapsed. Then, the pH-responsive self-assembly
system was utilized for controlled drug release.