PHOX2B promotes the occurrence and development of neuroblastoma by activating the MAPK signaling pathway. PHOX2B promotes the occurrence and development of neuroblastoma by activating the MAPK signaling pathway

Studies have shown that PHOX2B is the first predisposition gene identified in neuroblastoma.To explore PHOX2B-dependent gene regulation, RNA-seq analysis was performed. Compared with the control group, PHOX2B knockdown SK-N-BE(2) cells showed differently expressed genes. We found that PHOX2B activates the MAPK signaling pathway to promote the occurrence and development of neuroblastoma. Overall design: mRNA profiles of SK-N-BE(2) cells transfected with scramble shRNA (sh-Scb) or sh-PHOX2B were generated by RNA sequencing, in double, using Illumina NovaSeq6000.