Expression data from embryonic day 16.5 or postnatal day 3 mouse liver
收藏Alliance of Genome Resources2026-08-01 收录
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mRNA degradation critically contributes to liver development and function. The CCR4-NOT complex serves as a major deadenylase that initiates mRNA degradation. We used microarrays to identify deregulated genes in the livers lacking Cnot3, a core subunit of the CCR4-NOT complex. Liver-specific Cnot3 knockout mice were generated by expressing Cre recombinase under the control of Albumin promoter. Livers from control and CNOT3 knockout mice were used for RNA extraction and hybridization on Affymetrix microarrays.
