Investigation of intracellular speciation of a series organometallic hemilabile gold(III) complexes
收藏ESRF Portal2028-01-01 更新2026-04-23 收录
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https://doi.esrf.fr/10.15151/ESRF-ES-2166876714
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资源简介：
Chelating carbene-pyridine based organogold(III) complexes of general formula [(C^C)Au(C^N)]+ present antiproliferative activities from the low micromolar to the submicromolar range. Their mechanism of action is currently being investigated as they are potential anti-cancer agents. We observed a clearly different chemical reactivity and cytotoxicity among members of this family, which was related to the nature of the carbene and the N-donor ligands. We previously demonstrated the possibility to identify the speciation of gold(III) phosphine complexes by cryo-X-Ray Absorption Spectroscopy on beamline BM16[2, 3]. We now apply for beamtime on BM16 to perform cryo-XAS measurements on cancer cells treated with three different [(C^C)Au(C^N)]+ complexes to draw relationships between intracellular speciation, anticancer properties and chemical reactivity. This project is financially supported by ITMO Cancer (project Goldspec no. 23CP039-00).
提供机构：
CNRS / OSUG - UMS832, Observatoire des Sciences de l Univers, Domaine universitaire, Bâtiment Osug-a 414 Rue De La Piscine, 38400 Saint-martin-d Heres, France; CNRS, Institut Neel, BP166, 38042 Grenoble, France; Sorbonne Universite, Institut Parisien de Chimie Moleculaire-IPCM, 4 place Jussieu, 75005 Paris, France; ESRF, 71 avenue des Martyrs, CS 40220, 38043 Grenoble Cedex 9, France; CNRS , Laboratoire Louis Neel, 25 rue des Martyrs BP 166X, 38042 , Grenoble, FRANCE
创建时间：
2028-01-01
