Enantioselective, Catalytic Fluorolactonization Reactions with a Nucleophilic Fluoride Source
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https://figshare.com/articles/dataset/Enantioselective_Catalytic_Fluorolactonization_Reactions_with_a_Nucleophilic_Fluoride_Source/4015173
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资源简介：
The enantioselective
synthesis of 4-fluoroisochromanones via chiral aryl iodide-catalyzed
fluorolactonization is reported. This methodology uses HF-pyridine
as a nucleophilic fluoride source with a peracid stoichiometric oxidant
and provides access to lactones containing fluorine-bearing stereogenic
centers in high enantio- and diastereoselectivity. The regioselectivity
observed in these lactonization reactions is complementary to that
obtained with established asymmetric electrophilic fluorination protocols.
创建时间：
2016-10-20
