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p53 pulses lead to distinct patterns of gene expression albeit similar DNA-binding dynamics

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https://www.ncbi.nlm.nih.gov/sra/SRP109318
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资源简介:
Investigation of mechanism of gene regulation in response to pulses in p53 protein level induced by gamma irradiation. To directly connect p53 pulses with gene expression, we collected time-course ChIP-Seq and RNA-Seq data. Overall design: Time course p53, H3K27ac ChIP-Seq and RNA-Seq data in MCF7 cells treated with 10Gy gamma irradiation. As well as time course RNA-Seq data in MCF7 cells expressing p53shRNA.
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2018-01-10
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