ABM of tissue regeneration following VML injury

This agent-based model (ABM) simulates cellular behaviors following volumetric muscle loss (VML) injury to predict the tissue remodeling response. The simulation focuses on the dynamics of fibroblasts and satellite stem cells and incorporates the behaviors and interactions of muscle fibers, ECM, growth factors and pro-inflammatory and anti-inflammatory macrophages. The model has the ability to simulate the tissue regeneration following an unrepaired VML injury, an injury treated with decellularized ECM, or an injury treated with minced muscle graft. The project includes source code for the ABM. The model was built in Repast, a Java based modeling platform. <br/><br/>This project includes the following software/data packages: <br/> <ul> <li> <a href="https://simtk.org/frs?group_id=1849#pack_2169">ABM VML Source Code </a> : The source code for ABM of VML injury built in Repast. </li> </ul>

本基于智能体模型（ABM）模拟了细胞在体积性肌肉损失（VML）损伤后的行为，以预测组织重塑反应。该模拟专注于成纤维细胞和卫星干细胞的动力学，并纳入了肌纤维、细胞外基质（ECM）、生长因子以及促炎和抗炎巨噬细胞的行为了相互作用。该模型具备模拟未修复的VML损伤、使用去细胞化ECM治疗的损伤或使用切碎的肌瓣治疗的损伤后组织再生的能力。项目包含ABM的源代码。该模型是在基于Java的建模平台Repast中构建的。项目还包括以下软件/数据包：

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<li><a href="https://simtk.org/frs?group_id=1849#pack_2169">ABM VML源代码</a>：在Repast中构建的VML损伤ABM的源代码。</li>
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