Sterol 14-alpha demethylase (CYP51) from Trypanosoma brucei in complex with the VNI derivative (R)-N-(1-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethyl)-4-(5-phenyl-1,3,4-oxadiazol-2-yl)benzamide [R-VNI-triazole (VNT)]

Sterol 14-alpha demethylase (CYP51) from Trypanosoma brucei in complex with the VNI derivative (R)-N-(1-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethyl)-4-(5-phenyl-1,3,4-oxadiazol-2-yl)benzamide [R-VNI-triazole (VNT)] Descriptor: N-[(1R)-1-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethyl]-4-(5-phenyl-1,3,4-oxadiazol-2-yl)benzamide, PROTOPORPHYRIN IX CONTAINING FE, sterol 14-alpha-demethylase Authors: Hargrove, T.Y, Wawrzak, Z, Waterman, M.R, Lepesheva, G.I. Deposit date: 2012-07-14 Release date: 2013-07-17 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.83 Å) Cite: VFV as a New Effective CYP51 Structure-Derived Drug Candidate for Chagas Disease and Visceral Leishmaniasis. J Infect Dis, 212, 2015

本数据集记录布氏锥虫（Trypanosoma brucei）来源的甾醇14-α去甲基化酶（CYP51）与VNI衍生物(R)-N-(1-(2,4-二氯苯基)-2-(1H-1,2,4-三唑-1-基)乙基)-4-(5-苯基-1,3,4-恶二唑-2-基)苯甲酰胺[R-VNI三唑(VNT)]的复合物结构。
描述项：N-[(1R)-1-(2,4-二氯苯基)-2-(1H-1,2,4-三唑-1-基)乙基]-4-(5-苯基-1,3,4-恶二唑-2-基)苯甲酰胺、含铁原卟啉IX、甾醇14-α-去甲基化酶
作者：Hargrove, T.Y.、Wawrzak, Z.、Waterman, M.R.、Lepesheva, G.I.
存放日期：2012-07-14
发布日期：2013-07-17
最后修改日期：2023-09-13
实验方法：X射线衍射（分辨率1.83埃）
引用文献：《VFV作为基于CYP51结构的新型有效抗查加斯病及内脏利什曼病候选药物》，《传染病杂志》，2015年，第212卷