Analysis of lncRNA-mRNA co-expression profiles in CD133 positive cancer stem-like cells from osteosarcoma cell line Saos-2

Osteosarcoma (OS) is an essential threatening tumor of bone in young adults. OS stem cells (OSCs) act a significant role in the occurrence, metastasis, drug resistance and recurrence of OS. CD133 is an integral membrane glycoprotein, which has been identified as an OSCs marker. However, the mechanisms of metastasis, chemoresistance and progression in CD133(+) OSCs need to be further explored. We aim to detect the lncRNA and mRNA profiles in CD133(+) cells compared with CD133(-) cells from the Saos-2 cell line in the present study. Overall design: The expression of lncRNAs and mRNAs in CD133(+) cells compared with CD133(-) cells from the Saos-2 cell line was explored by high-throughput sequencing and differentially expressed (DE) lncRNAs and DEmRNAs were obtained. Comparative The expression of lncRNAs and mRNAs in CD133(+) cells compared with CD133(-) cells from the Saos-2 cell line.