Crystal structure of HCV NS3 protease with a boronate inhibitor

Crystal structure of HCV NS3 protease with a boronate inhibitor Descriptor: CYCLOPENTYL N-[(2S)-1-[(2S,4R)-2-[[(4R)-8-HYDROXY-1,6,10-TRIOXA-5$L^{4}-BORASPIRO[4.5]DECAN-4-YL]CARBAMOYL]-4-ISOQUINOLIN-1-YLOXY-PYRROLIDIN-1-YL]-3,3-DIMETHYL-1-OXO-BUTAN-2-YL]CARBAMATE, MAGNESIUM ION, NS3 PROTEASE, ... Authors: Li, X, Zhang, Y.-K, Liu, Y, Ding, C.Z, Li, Q, Zhou, Y, Plattner, J.J, Baker, S.J, Qian, X, Fan, D, Liao, L, Ni, Z.-J, White, G.V, Mordaunt, J.E, Lazarides, L.X, Slater, M.J, Jarvest, R.L, Thommes, P, Ellis, M, Edge, C.M, Hubbard, J.A, Nassau, P, McDowell, B, Skarzynski, T.J, Rowland, P, Somers, D.O, Kazmierski, W.M, Grimes, R.M, Wright, L.L, Smith, G.K, Zou, W, Wright, J, Pennicott, L.E. Deposit date: 2010-04-22 Release date: 2010-06-02 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (2.48 Å) Cite: Synthesis and Evaluation of Novel Alpha-Amino Cyclic Boronates as Inhibitors of Hcv Ns3 Protease. Bioorg.Med.Chem.Lett., 20, 2010

含硼酸酯抑制剂的丙型肝炎病毒（HCV）NS3蛋白酶晶体结构
描述符：环戊基 N-[(2S)-1-[(2S,4R)-2-[[(4R)-8-羟基-1,6,10-三氧杂-5λ⁴-硼杂螺[4.5]癸烷-4-基]氨基甲酰基]-4-异喹啉-1-基氧基吡咯烷-1-基]-3,3-二甲基-1-氧代丁烷-2-基]氨基甲酸酯、镁离子、NS3蛋白酶……
作者：Li, X、Zhang, Y.-K、Liu, Y、Ding, C.Z、Li, Q、Zhou, Y、Plattner, J.J、Baker, S.J、Qian, X、Fan, D、Liao, L、Ni, Z.-J、White, G.V、Mordaunt, J.E、Lazarides, L.X、Slater, M.J、Jarvest, R.L、Thommes, P、Ellis, M、Edge, C.M、Hubbard, J.A、Nassau, P、McDowell, B、Skarzynski, T.J、Rowland, P、Somers, D.O、Kazmierski, W.M、Grimes, R.M、Wright, L.L、Smith, G.K、Zou, W、Wright, J、Pennicott, L.E
入库日期：2010-04-22
发布日期：2010-06-02
最后修改日期：2024-05-08
测试方法：X射线衍射（分辨率2.48 Å）
引用文献：《新型α-氨基环状硼酸酯类HCV NS3蛋白酶抑制剂的合成与评价》，Bioorg.Med.Chem.Lett.，2010年，第20卷