Highly Diastereoselective Synthesis of C(6)-Functionalized Dihydroimidazotriazines
收藏NIAID Data Ecosystem2026-03-06 收录
下载链接：
https://figshare.com/articles/dataset/Highly_Diastereoselective_Synthesis_of_C_6_Functionalized_Dihydroimidazotriazines/3358528
下载链接
链接失效反馈官方服务：
资源简介：
The first examples of C(6)-substituted 7-hydroxy-6,7-dihydro-5H-imidazo[1,2-b][1,2,4]triazines have been prepared by ring closure of different
5(2H)-1,2,4-triazin-3-ones 1a−c with 40% aqueous glyoxal and various nucleophiles (alcohols, thiols, or amines). The structure and exact
stereochemistry of 2a was established by a single X-ray diffraction study and 1H and 13C NMR spectra analysis. The process was shown to
be totally regio- and diastereoselective. A mechanism involving an imine intermediate was proposed.
创建时间：
2016-05-07
