Serum Protein Levels of TH1 and TH2 Cytokines.

Values are means ± SE (n = 6);apbpcpdp$Below detection limit. In serum, the TH2 cytokines IL-4, IL-5 and IL-13, were significantly increased in the NO2+OVA group, but not in the NO2+OVA+CNP group. Exposure to NO2 significantly increased serum TNF-α expression, in all of the exposed groups, which was remarkably higher in both of the OVA-sensitized groups; NO2+OVA and NO2+OVA+CNP vs. NO2+Saline and NO2+CNP. In the NO2+OVA and NO2+OVA+CNP groups, the levels of IL1-b were significantly increased compared to their air-exposed counterparts. The combination of NO2 exposure and CNP treatment significantly increased the IFN-g levels; however, the level of this cytokine was again significantly lower in the NO 2+OVA+CNP group. The KC/GRO levels were increased following NO2 exposure, with substantial elevations in NO2+OVA and NO2+OVA+CNP groups compared to Air+Saline, with notable within-group variability.