HEK293T cells transduced with shRNA from MISSION library TRCN0000049368 using lentiviral delivery system. HEK293T cells transduced with scrambled shRNA, gifted from Dr. Mauricio Reginato. Tara L Davis

NIAID Data Ecosystem30

Context-specific interactomes and the datasets used to reverse engineer them.

蛋白质相互作用组学

生物网络反向工程

Context-specific interactomes and the datasets used to reverse engineer them.

Figshare2017-10-13 更新30

Data_Sheet_1_Impaired interactions of ataxin-3 with protein complexes reveals their specific structure and functions in SCA3 Ki150 model.docx

神经退行性分子机制

蛋白质相互作用组学

Spinocerebellar ataxia type 3 (SCA3/MJD) is a neurodegenerative disease caused by CAG expansion in mutant ATXN3 gene. The resulting PolyQ tract in mutant ataxin-3 protein is toxic to neurons and curre

NIAID Data Ecosystem30

Signal Attrition in Whole Cell Cross-Linking Mass Spectrometry

交联质谱

蛋白质相互作用组学

Cross-linking mass spectrometry (XL-MS) could replace traditional techniques for sampling the cellular interactome, such as affinity pulldown MS. It generates superior interaction data that can be use

NIAID Data Ecosystem30