Effect of Remote Ischemic Preconditioning in Patients Undergoing Laparoscopic Colorectal Cancer Surgery

This was a prospective, randomized trial of RIPC versus placebo-controlled in patients undergoing elective laparoscopic CRC surgery. A total of 80 patients were randomized to a RIPC group or a control group (40 per arm), randomization was computer-generated. Patients with planned enterostomy formation was excluded. Patients in the RIPC group received RIPC for a total of about 30 minutes (3 cycles of 5 minutes ischemia and 5 minutes reperfusion in upper limb with cuff pressure at 26.7 kPa [200 mm Hg]) prior to the start of surgery. Patients in the control group received sham RIPC for a total of about 30 minutes (the cuff was not inflated). The aim was to determine whether RIPC improved recovery of gut function. The primary outcomes were time to gastrointestinal tolerance and incidence of PPOI. Secondary outcomes were time to flatus, time to stool, time to diet, postoperative duration of hospital stay, nasogastric tube (NGT) required, intravenous nutrition (IVN) required, results of blood biochemical tests, and postoperative complications.