Crystal structure of zebrafish prostacyclin synthase (cytochrome P450 8A1) in complex with substrate analog U51605

Crystal structure of zebrafish prostacyclin synthase (cytochrome P450 8A1) in complex with substrate analog U51605 Descriptor: (5Z)-7-{(1R,4S,5R,6R)-6-[(1E)-oct-1-en-1-yl]-2,3-diazabicyclo[2.2.1]hept-2-en-5-yl}hept-5-enoic acid, PROTOPORPHYRIN IX CONTAINING FE, Prostaglandin I2 synthase Authors: Li, Y.-C, Chiang, C.-W, Yeh, H.-C, Hsu, P.-Y, Whitby, F.G, Wang, L.-H, Chan, N.-L. Deposit date: 2007-11-03 Release date: 2007-11-20 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Structures of Prostacyclin Synthase and Its Complexes with Substrate Analog and Inhibitor Reveal a Ligand-specific Heme Conformation Change J.Biol.Chem., 283, 2008

斑马鱼前列腺环素合酶（prostacyclin synthase，细胞色素P450 8A1）与底物类似物（substrate analog）U51605结合的晶体结构。结构描述符：(5Z)-7-{(1R,4S,5R,6R)-6-[(1E)-辛-1-烯-1-基]-2,3-二氮杂双环[2.2.1]庚-2-烯-5-基}庚-5-烯酸、含亚铁的原卟啉IX（PROTOPORPHYRIN IX）、前列腺素I2合酶（Prostaglandin I2 synthase）。作者：Li, Y.-C、Chiang, C.-W、Yeh, H.-C、Hsu, P.-Y、Whitby, F.G、Wang, L.-H、Chan, N.-L。提交日期：2007-11-03；发布日期：2007-11-20；最后修改日期：2023-11-01。实验方法：X射线衍射（X-RAY DIFFRACTION，分辨率2.5埃）。引用文献：《前列腺环素合酶及其与底物类似物和抑制剂的复合物结构揭示配体特异性血红素（heme）构象变化》，发表于《生物化学杂志》（J. Biol. Chem.），2008年，第283卷。