Transcriptomic analysis of high-fat diet-fed mice treated with CYP4A inhibitors

Cytochrome P4504A (CYP4A) is known to be related to the development of type 2 diabetes (T2DM) and non-alcoholic fatty liver disease (NAFLD). We discovered selective CYP4A inhibitors, C481 (C1) and C482 (C2), and confirmed the therapeutic effects of these inhibitors on T2DM and NAFLD. In order to confirm the mechanisms of C1 and C2, inhibitors were treated in high-fat diet (HFD)-fed mice and RNA sequencing was performed using the liver tissues. Overall design: Comparative gene expression profiling of RNA-seq data from the liver of HFD-fed mice and HFD-fed mice treated with C1 or C2.