Cinchona Alkaloid Derived Iodide Catalyzed Enantioselective Oxidative α‑Amination of Carbonyl Compounds toward the Construction of Spiroindolyloxindole

Novel cinchona alkaloid derived iodide
catalysts were developed
for the enantioselective oxidative α-amination of 2-oxindoles,
providing various functionalized spiropyrrolidine oxindoles in high
yields and with good enantioselectivities. This iodide/ROOH catalytic
system features a one-step synthesis of a catalyst with multiple functionalities,
ease of operation, and good scalability, thereby enriching the repertoire
of iodide catalysis for enantioselective oxidative coupling reactions.