Impact of GNA13 knockdown on gene expression changes in PC3 cells

GNA13 has been shown to have multiple oncogenic roles in many different solid tumors including prostate cancers. However, the molecular mechanisms that drive GNA13-induced oncogenesis and metastasis is not understood completely. To elucidate the mechanisms driven by GNA13 in prostate cancer cells, we performed total RNA sequencing in PC3 cells after knocking down GNA13 expression using two different shRNAs. RNA sequencing of PC3 cells stably expressing GNA13-targeting shRNAs or control shRNA.