INPP5D PanDDA analysis group deposition -- Crystal Structure of the phosphatase and C2 domains of SHIP1 in complex with Z2856434879

INPP5D PanDDA analysis group deposition -- Crystal Structure of the phosphatase and C2 domains of SHIP1 in complex with Z2856434879 Descriptor: 2-[(4-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroisoquinoline, DIMETHYL SULFOXIDE, Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 Authors: Bradshaw, W.J, Newman, J.A, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Gileadi, O. Deposit date: 2020-10-30 Release date: 2020-11-11 Last modified: 2026-02-18 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Regulation of inositol 5-phosphatase activity by the C2 domain of SHIP1 and SHIP2. Structure, 2024

INPP5D PanDDA分析组提交数据——结合Z2856434879的SHIP1磷酸酶结构域与C2结构域（C2 domain）的晶体结构，配体描述：2-[(4-甲基-1H-咪唑-5-基)甲基]-1,2,3,4-四氢异喹啉、二甲基亚砜（Dimethyl sulfoxide）、磷脂酰肌醇3,4,5-三磷酸5-磷酸酶1（Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1）；作者：W.J. Bradshaw、J.A. Newman、F. von Delft、C.H. Arrowsmith、A.M. Edwards、C. Bountra、O. Gileadi；提交日期：2020-10-30；发布日期：2020-11-11；最后修改日期：2026-02-18；实验方法：X射线衍射（1.4 Å）；引用文献：《通过SHIP1与SHIP2的C2结构域调控肌醇5-磷酸酶活性》，《Structure》，2024年。