Population genetic analyses of vaginal microbiome. Population genetic analyses of longitudinal vaginal microbiome reveal racioethnic evolutionary dynamics and prevailing positive selection genes

The vaginal microbiome is important for reproductive health. Lactobacillaceae-dominated vaginal microbiomes are often considered healthy. The vaginal microbiome composition is associated with ethnicity. However, the evolutionary landscape of the vaginal microbiome, especially in the multi-ethnic context, remains elusive. Herein, we performed a longitudinal evolutionary vaginal microbiome analysis of 319 samples from 35 pregnant women from diverse ethnic backgrounds.