Diastereoselective ABB′ Three-Component Synthesis of Highly Functionalized Spirooxindoles Bearing Five Consecutive Asymmetric Carbons
收藏NIAID Data Ecosystem2026-03-11 收录
下载链接：
https://figshare.com/articles/dataset/Diastereoselective_ABB_Three-Component_Synthesis_of_Highly_Functionalized_Spirooxindoles_Bearing_Five_Consecutive_Asymmetric_Carbons/7877855
下载链接
链接失效反馈官方服务：
资源简介：
The synthesis of spirooxindoles bearing
tetrahydro-4H-cyclopenta[b]furan
framework was established starting
from isatin-derived aldehydes and 2 equiv of 1,3-dicarbonyl compounds
involving a piperidine-catalyzed ABB′ three-component domino
process. This reaction was highly diastereoselective affording a single
diastereomer of spirooxindoles with five consecutive asymmetric carbons
including spiro and tetrasubstituted carbon centers. In addition,
this waste-free (−2H2O) reaction showed high atom
economy and step economy by creating four new bonds, including three
C–C bonds and one C–O bond, and two rings (one carbo-
and one heterocyclic) in a single operation. The mechanism of this
three-component domino process involved sequential Knoevenagel condensation–Michael
addition–intramolecular oxa-Michael addition–intramolecular
aldol reactions.
创建时间：
2019-03-21
