Mapping Gata2 enhancer-dependent developmental trajectories by single-cell RNA-sequencing
收藏Alliance of Genome Resources2026-08-01 收录
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We compared single-cell transcriptomes of fetal liver myeloid progenitor pools (CMP/GMP pool) from Gata2 -77 enhancer mutant embryos and wildtype littermates. Gene expression patterns in -77-deficient mice demonstrated loss of erythroid, megakaryocyte and granulocyte progenitors and an increase in monocyte Lineage-Sca1-cKit+CD34+ cells from E14.5 fetal livers of two wild type and two -77-deleted embryos were processed for single-cell RNA sequencing using 10x Genomics Chromium platform.
