Human p38 alpha MAPK in complex with a pyridazine based inhibitor

Human p38 alpha MAPK in complex with a pyridazine based inhibitor Descriptor: 3-phenyl-4-(pyridin-4-yl)-6-[4-(pyrimidin-2-yl)piperazin-1-yl]pyridazine, 4-[3-(4-FLUOROPHENYL)-1H-PYRAZOL-4-YL]PYRIDINE, ACETATE ION, ... Authors: Grum-Tokars, V, Minasov, G, Roy, S, Schavocky, J, Winsor, J, Watterson, D.M, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID) Deposit date: 2012-04-27 Release date: 2012-06-27 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.1 Å) Cite: A Selective and Brain Penetrant p38 alpha MAPK Inhibitor Candidate for Neurologic and Neuropsychiatric Disorders That Attenuates Neuroinflammation and Cognitive Dysfunction. J.Med.Chem., 62, 2019

与哒嗪类抑制剂结合的人源p38α丝裂原活化蛋白激酶（MAPK）。描述物：3-苯基-4-(吡啶-4-基)-6-[4-(嘧啶-2-基)哌嗪-1-基]哒嗪、4-[3-(4-氟苯基)-1H-吡唑-4-基]吡啶、乙酸根离子……。作者：Grum-Tokars V、Minasov G、Roy S、Schavocky J、Winsor J、Watterson D.M.、Anderson W.F.，感染性疾病结构基因组学中心（CSGID）。存入日期：2012-04-27；发布日期：2012-06-27；最后修改日期：2023-09-13。实验方法：X射线衍射（分辨率2.1 Å）。引用文献：《一种兼具选择性与血脑屏障穿透性的p38α丝裂原活化蛋白激酶抑制剂候选物——用于减轻神经炎症与认知功能障碍的神经及神经精神疾病治疗》，《J.Med.Chem.》，62卷，2019年。