Palladium-Catalyzed Regio- and Enantioselective Synthesis of Allylic Amines Featuring Tetrasubstituted Tertiary Carbons

The first asymmetric synthesis of
α,α-disubstituted
allylic N-arylamines based on a palladium-catalyzed
allylic amination has been developed. The protocol uses highly modular
vinyl cyclic carbonates and unactivated aromatic amine nucleophiles
as substrates. The catalytic process features minimal waste production,
ample scope in reaction partners, high asymmetric induction up to
97% ee, and operational simplicity.